Eosinophilic Granulomatosis with Polyangiitis (EGPA): A case report with atypical presentation

  • Khalid Mehmood Azra Naheed Medical College, Superior University Lahore Pakistan
  • Nauman Ismat Butt Azra Naheed Medical College, Superior University Lahore Pakistan
  • Fahmina Ashfaq Azra Naheed Medical College, Superior University Lahore Pakistan
  • Sabeen Aftab Azra Naheed Medical College, Superior University Lahore Pakistan
Keywords: Eosinophilic Granulomatosis With Polyangiitis, ANCA-associated Vasculitis, Pulmonary Vasculitis, Eosinophilia

Abstract

A 72-year-old asthmatic gentleman with a history of recurrent sinusitis and chronic bronchitis presented with shortness of breath and progressively worsening hypoxemic respiratory failure. His CT chest demonstrated airspace disease bilaterally with ground-glass opacifications. He had peripheral eosinophilia with raised inflammatory markers but negative work up of infection. On further investigation, ANA was positive, titer 1:160, speckled pattern and both pANCA and cANCA were present. The patient was diagnosed with Eosinophilic Granulomatosis with Polyangiitis (EGPA) and started on intravenous steroids and cyclophosphamide. A rare multi-organ vasculitis, EGPA is hallmarked by asthma, sinusitis and eosinophilia. In initial stages vasculitic involvement is not usually seen thereby making EGPA a diagnostic challenge.

doi: https://doi.org/10.12669/pjms.39.1.6436

How to cite this: Mahmood K, Butt NI, Ashfaq F, Aftab S. Eosinophilic Granulomatosis with Polyangiitis (EGPA): A case report with atypical presentation. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.6436

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2022-11-16
How to Cite
Mehmood, K., Butt, N. I., Ashfaq, F., & Aftab, S. (2022). Eosinophilic Granulomatosis with Polyangiitis (EGPA): A case report with atypical presentation. Pakistan Journal of Medical Sciences, 39(1). https://doi.org/10.12669/pjms.39.1.6436