TY - JOUR AU - Mehmood, Khalid AU - Butt, Nauman Ismat AU - Ashfaq, Fahmina AU - Aftab, Sabeen PY - 2022/12/03 Y2 - 2024/03/28 TI - Eosinophilic Granulomatosis with Polyangiitis (EGPA): A case report with atypical presentation JF - Pakistan Journal of Medical Sciences JA - Pak J Med Sci VL - 39 IS - 1 SE - Case Reports DO - 10.12669/pjms.39.1.6436 UR - https://pjms.org.pk/index.php/pjms/article/view/6436 SP - AB - A 72-year-old asthmatic gentleman with a history of recurrent sinusitis and chronic bronchitis presented with shortness of breath and progressively worsening hypoxemic respiratory failure. His CT chest demonstrated airspace disease bilaterally with ground-glass opacifications. He had peripheral eosinophilia with raised inflammatory markers but negative work up of infection. On further investigation, ANA was positive, titer 1:160, speckled pattern and both pANCA and cANCA were present. The patient was diagnosed with Eosinophilic Granulomatosis with Polyangiitis (EGPA) and started on intravenous steroids and cyclophosphamide. A rare multi-organ vasculitis, EGPA is hallmarked by asthma, sinusitis and eosinophilia. In initial stages vasculitic involvement is not usually seen thereby making EGPA a diagnostic challenge.doi: https://doi.org/10.12669/pjms.39.1.6436How to cite this: Mahmood K, Butt NI, Ashfaq F, Aftab S. Eosinophilic Granulomatosis with Polyangiitis (EGPA): A case report with atypical presentation. Pak J Med Sci. 2023;39(1):307-309. doi: https://doi.org/10.12669/pjms.39.1.6436This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ER -