Effect of Remdesivir on mortality and length of stay in hospitalized COVID-19 patients: A single center study

  • Quratulain Shaikh Indus Hospital Karachi
  • Samreen Sarfaraz
  • Anum Rahim
  • Mujahid Hussain
  • Rabeea Shah
  • Sara Soomro
Keywords: COVID-19, Remdesivir, Mortality, ARDS

Abstract

Objectives: To see the difference in mortality among hospitalized COVID-19 patients given Remdesivir (RDV) with those who were not given RDV.

Methods: A prospective cohort study was conducted on patients who were admitted to the COVID-19 isolation unit at The Indus Hospital, Korangi Campus Karachi between March and June 2020.

Results: Groups were similar in age and gender distribution. RDV group was more hypoxic, had severe ARDS and needed higher Oxygen support compared to non-RDV group (p=0.000). Median SOFA score was 2 in RDV vs 5 in non-RDV (p=0.000). More than moderate COVID pneumonia was found in 92% of the RDV group while 89% of non-RDV group (p value=0.001). Median day of illness to administer Remdesivir was 10. There was no difference in mortality (45.5% in RDV vs 40.4% in non-RDV; p=0.4) between the two groups. Median length of hospital stay was 12 days (IQR=7.5-14.5) in RDV group compared to 10 days (IQR=6-14) in non-RDV group (p=0.009).

Conclusion: RDV did not show any difference in in-hospital mortality in our patients. More patients had severe ARDS in the RDV group while patients in the non-RDV group had higher SOFA score and multi-organ failure. Length of stay was longer in patients receiving Remdesivir.

doi: https://doi.org/10.12669/pjms.38.ICON-2022.5779

How to cite this:
Shaikh Q, Sarfaraz S, Rahim A, Hussain M, Shah R, Soomro S. Effect of Remdesivir on mortality and length of stay in hospitalized COVID-19 patients: A single center study. Pak J Med Sci. 2022;38(2):405-410.  doi: https://doi.org/10.12669/pjms.38.ICON-2022.5779

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2021-12-15
How to Cite
Shaikh, Q., Sarfaraz, S., Rahim, A., Hussain, M., Shah, R., & Soomro, S. (2021). Effect of Remdesivir on mortality and length of stay in hospitalized COVID-19 patients: A single center study. Pakistan Journal of Medical Sciences, 38(ICON-2022). https://doi.org/10.12669/pjms.38.ICON-2022.5779