Correlation between Serum Ferritin Levels and Liver Stiffness measured by Fibroscan in patients with Chronic Hepatitis C

Serum Ferritin Levels & Liver Stiffness in HCV patients

  • Saba Latif Patel Hospital
  • Quratulain Kalam Patel Hospital
  • Bader Faiyaz Zuberi Dow University of Health Sciences
Keywords: Fibroscan, Transient Elastography, Chronic hepatitis C, Ferritin

Abstract

Objective: To determine correlation between transient elastography values with serum ferritin and duration of infection in patients of hepatitis C.

Methods: A cross-sectional study was conducted at medical units of Civil Hospital, Karachi. The study protocol was approved by the Research Evaluation Unit of College of Physician and Surgeon Pakistan (CPSP). Patients fulfilling inclusion criteria were included after taking informed consent. Serum ferritin levels were tested by standard laboratory procedures and transient elastography by fibroscan. Regression analysis was done to see correlation of ferritin with transient elastography and duration of HCV.

Results: Over all 120 patients fulfilling the selection criteria were selected after informed consent. These included 68 (56.7%) male & 52 (43.3%) female. Significant differences in ferritin levels by Fibrosis stages were observed by ANOVA (df = 3; F =12.768; p = <0.001). Serum ferritin showed linear pattern across Fibrosis stages (F = 33.948; p = <0.001). Regression analysis of ferritin and duration of HCV showed significant impact on TE scores (r2 = 0.317).

Conclusions: There is significant correlation between serum ferritin and duration of HCV with TE scores.

doi: https://doi.org/10.12669/pjms.36.3.1288

How to cite this:
Latif S, Kalam Q, Zuberi BF. Correlation between Serum Ferritin Levels and Liver Stiffness measured by Fibroscan in patients with Chronic Hepatitis C. Pak J Med Sci. 2020;36(3):355-359. doi: https://doi.org/10.12669/pjms.36.3.1288

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Saba Latif, Patel Hospital

Consultant Physician

Quratulain Kalam, Patel Hospital

Consultant Physician

Published
2020-03-03
Section
Original Articles