@article{Lu_Liu_Luo_Xiao_2023, title={Relationship between Monoclonal Gammopathy of undetermined significance and multiple myeloma via online database analysis}, volume={39}, url={https://pjms.org.pk/index.php/pjms/article/view/7206}, DOI={10.12669/pjms.39.3.7206}, abstractNote={<p><em><strong>Objective:</strong> </em>To explore the relationship between Monoclonal Gammopathy of undetermined significance (MGUS) and Multiple Myeloma (MM) based on bioinformatics methods.</p> <p><em><strong>Methods:</strong></em> In this study, we conducted bioinformatics to identify genes associated with MGUS and MM using the PubMed pubmed2ensemble (http://pubmed2ensembl.ls.manchester. ac.uk/) until 2021. Gene ontology function was used to label overlapping genes, and Kyoto Encyclopedia of Genes and Genomes analysis was used to identify enriched pathways. The cluster-1 genes obtained from Cytoscape were analyzed by Comparative Toxicogenomics Database (CTD, http://ctdbase.org/) and then used to screen candidate drugs using the DSigDB database (https://amp.pharm.mssm.edu/Enrichr/).</p> <p><em><strong>Results:</strong></em> In total, 227 genes were common to both MGUS and MM. These genes were significantly associated with cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. The protein-protein interaction network revealed that TNF, IL-1B, IL-6, CSF2, CXCL8, and IL-10 were among the core genes of MM. Finally, eight candidate drugs showed maximum interaction with core genes, which could potentially prevent MGUS from progressing to MM.</p> <p><em><strong>Conclusion:</strong></em> The progression of MGUS to MM is driven by aberrant cytokine secretion, which leads to inflammation immune dysfunction, and dysregulation of the PI3K/AKT/mTOR signaling pathway.</p> <p><strong>doi: https://doi.org/10.12669/pjms.39.3.7206</strong></p> <p><em><strong>How to cite this:</strong></em> Lu W, Liu J, Luo M, Xiao M. Relationship between Monoclonal Gammopathy of undetermined significance and multiple myeloma via online database analysis. Pak J Med Sci. 2023;39(3):715-720. doi: https://doi.org/10.12669/pjms.39.3.7206</p> <p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p&gt;}, number={3}, journal={Pakistan Journal of Medical Sciences}, author={Lu, Weiguo and Liu, Jiaming and Luo, Man and Xiao, Mingfeng}, year={2023}, month={Mar.} }