@article{Baig_Gazzaz_Bakarman_Alzahrani_2021, title={Correlation of Serum Vaspin, Omentin-1, and adiponectin with metabolic phenotypes in Type-2 diabetes mellitus patients: Adipocytokines and T2DM}, volume={37}, url={https://pjms.org.pk/index.php/pjms/article/view/4330}, DOI={10.12669/pjms.37.7.4330}, abstractNote={<p><em><strong>Objectives:</strong></em> To investigate adipocytokines’ (vaspin, omentin-1, and adiponectin) correlation with metabolic phenotypes in type 2 diabetes mellitus (T2DM) patients.&nbsp;</p> <p><em><strong>Methods:</strong></em> This case-control research was done at the Diabetic Clinic in Jeddah, Kingdom of Saudi Arabia (KSA), from November 2018 to March 2019. Seventy-five T2DM patients and 75 gender, age, and BMI-matched healthy subjects were recruited for this research.&nbsp;</p> <p><em><strong>Results:</strong></em> In DM patients, the concentrations of serum vaspin and omentin-1 were substantially lower (p&lt;0.001) than in the control group. A significant positive relationship between vaspin concentration and DBP (p&lt;0.001), BMI (p&lt;0.001), and waist circumference (p&lt;0.001) was found in patients and control subjects, while FPG (p&lt;0.016), serum insulin (p&lt;0.001), HOMA-IR (p&lt;0.001), TC (p&lt;0.001), TG (p&lt;0.001), and LDLc (p&lt;0.001) were significantly interrelated among patients. Serum concentrations of omentin-1 and ADN were significantly negatively correlated with serum insulin, HOMA-IR, and TG among the DM group. Serum vaspin and ADN levels were significantly higher in the cases and control groups with BMI&gt;25, and no gender-wise variance was observed in adipocytokines levels. Binary logistic regression analysis showed a significantly negative predictive relationship of vaspin and omentin-1 with DM.</p> <p><em><strong>Conclusion:</strong></em> The DM group displayed substantially lower serum vaspin and omentin-1 levels. However, there was no consistent relationship observed between these adipocytokines and metabolic phenotypes.</p> <p><strong>doi: https://doi.org/10.12669/pjms.37.7.4330</strong></p> <p><em><strong>How to cite this:<br></strong></em>Baig M, Gazzaz ZJ, Bakarman MA, Alzahrani SH. Correlation of Serum Vaspin, Omentin-1, and adiponectin with metabolic phenotypes in Type-2 diabetes mellitus patients. Pak J Med Sci. 2021;37(7):1762-1767.&nbsp; &nbsp;doi: https://doi.org/10.12669/pjms.37.7.4330</p> <p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p&gt;}, number={7}, journal={Pakistan Journal of Medical Sciences}, author={Baig, Mukhtiar and Gazzaz, Zohair J and Bakarman, Marwan A and Alzahrani, Sami H}, year={2021}, month={Oct.} }