@article{Wang_Huang_Hu_Cai_Hu_Zhu_2020, title={Bloodstream infections in patients undergoing extracorporeal membrane oxygenation}, volume={36}, url={https://pjms.org.pk/index.php/pjms/article/view/2882}, DOI={10.12669/pjms.36.6.2882}, abstractNote={<p><em><strong>Objective:</strong></em> We aimed to evaluate the incidence, risk factors, and prognosis of bloodstream infections (BSIs) during extracorporeal membrane oxygenation (ECMO) treatment in a Chinese population.</p> <p><em><strong>Methods:</strong></em> Patients receiving ECMO treatment from January 2013 to August 2019 were retrospectively studied. The incidence of BSIs was calculated. The clinical characteristics between patients with a BSI (BSI group) and without a BSI (non-BSI group).</p> <p><em><strong>Results:</strong></em> Among 69 included patients, 19 (27.5%) developed at least one BSI. Gram-negative bacteria (73.7%) were mainly responsible for the BSIs, with Klebsiella pneumoniae (6/19, 31.5%) ranking as the top related pathogen. The BSI group had a greater proportion of methicillin-resistant Staphylococcus aureus (MRSA) prophylactic regimens (52.6% vs. 26.0%, P = 0.036), a higher pre-ECMO Sequential Organ Failure Assessment (SOFA) score (11 vs. 8, P = 0.008), more applications of continuous renal replacement therapy (CRRT) during ECMO (63.1% vs. 36.1%, P = 0.042). Longer ECMO support duration, period of ventilator use before ECMO weaning and hospital stay were observed in the BSI group. The SOFA score (OR: 1.174; 95% CI: 1.039–1.326; P = 0.010) was an independent risk factor for BSIs.</p> <p><em><strong>Conclusion:</strong></em> BSIs during ECMO therapy frequently involve Gram-negative bacteria. Stringent care and monitoring should be provided for patients with high SOFA scores.</p> <p><strong>doi: https://doi.org/10.12669/pjms.36.6.2882</strong></p> <p><em><strong>How to cite this:</strong></em><br>Wang JR, Huang JY, Hu W, Cai XY, Hu WH, Zhu Y. Bloodstream infections in patients undergoing extracorporeal&nbsp;membrane oxygenation. Pak J Med Sci. 2020;36(6):1171-1176. doi: https://doi.org/10.12669/pjms.36.6.2882</p> <p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p&gt;}, number={6}, journal={Pakistan Journal of Medical Sciences}, author={Wang, Jian-rong and Huang, Jin-yu and Hu, Wei and Cai, Xue-ying and Hu, Wei-hang and Zhu, Ying}, year={2020}, month={Aug.} }