Clinical value of Vitamin-D combined with budesonide/formoterol and theophylline sodium glycinate sustained-release tablets in the treatment of chronic obstructive pulmonary disease patients

Xiuyuan Ni; Shigeng Zhou; Congling Wang; Shengheng Chen; Jingdan Hu; Shengjing Zhang

doi:10.12669/pjms.40.7.9495

Xiuyuan Ni
Shigeng Zhou
Congling Wang
Shengheng Chen
Jingdan Hu
Shengjing Zhang Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Traditional Chinese Medicine

DOI: https://doi.org/10.12669/pjms.40.7.9495

Keywords: Chronic obstructive pulmonary disease, Budesonide/formoterol, Theophylline sodium glycinate sustained-release tablets, Vitamin-D

Abstract

Objective: To explore the clinical value of Vitamin-D combined with budesonide/formoterol (BF) and theophylline sodium glycinate (TSG) sustained-release tablets in the treatment of patients with chronic obstructive pulmonary disease (COPD).

Methods: Medical records of 114 patients with CODP, treated in Wenzhou Geriatric Hospital from October 2020 to February 2023, were retrospectively analyzed. Of them, 59 received treatment with Vitamin-D combined with BF and TSG sustained-release tablets (Group-A), and 55 patients received treatment with BF combined with TSG sustained-release tablets (Group-B). Lung function indicators, blood gas status, inflammatory factors, fractional exhaled nitric oxide (FeNO), and 25-hydroxyvitamin D [25(OH)D] levels before and after the treatment in both groups were collected.

Results: After the treatment, lung function indicators, blood gas status, inflammatory factors, FeNO, and 25 (OH) D levels in both groups were significantly improved compared to pretreatment levels, and were significantly better in the Group-A compared to Group-B (P<0.05).

Conclusions: The combination of Vitamin-D, BF, and TSG sustained-release tablets can effectively regulate the blood gas status of patients with COPD, improve lung function, regulate FeNO and 25 (OH) D, and effectively downregulate the levels of inflammatory factors, thus reducing the degree of inflammatory response.

doi: https://doi.org/10.12669/pjms.40.7.9495

How to cite this: Ni X, Zhou S, Wang C, Chen S, Hu J, Zhang S. Clinical value of Vitamin-D combined with budesonide/formoterol and theophylline sodium glycinate sustained-release tablets in the treatment of chronic obstructive pulmonary disease patients. Pak J Med Sci. 2024;40(7):1391-1396. doi: https://doi.org/10.12669/pjms.40.7.9495

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