Outcomes of Radioactive Iodine (131I) Therapy among Hyperthyroid patients

  • Muhammad Sajjad Ali Khan
  • Arshad Hussain
  • Shahzad Ahmad
  • Muhammad Harris Shah
Keywords: I-131, Radioactive Iodine, Hyperthyroidism, Treatment Effectiveness


Objective: The present study aimed to assess the thyroid outcomes six-months after radioactive Iodine-131 therapy (RIT) among hyperthyroid patients and identify the factors associated with them.

Methods: This retrospective observational study was conducted at the department of Nuclear Medicine and Molecular Imaging, Northwest General Hospital & Research Centre during 2013 to 2019. For the study purpose, the thyroid outcomes of 153 hyperthyroid patients were studied retrospectively for six months after RIT. The data was obtained from the medical records. Patient baseline characteristics, clinical features, laboratory investigations, results of thyroid imaging, and therapeutic investigations were acquired and recorded in a structured questionnaire.

Results: Out of the 153 screened records of hyperthyroid patients, 19.6% became euthyroid, 9.2% remained hyperthyroid, and 25.5% developed hypothyroidism after six months of RIT. The observed remission rate by the end of six months was 80.95%. Three months post-RIT, gender and RAI doses had a significant effect on thyroid function. The frequency of hypothyroidism was higher among those treated with an RAI dose of ≤ 20 mCi (83.0%) than those treated with a higher dose > 20 mCi (17%). Moreover, most patients receiving > 20 mCi radioiodine became euthyroid (64.5%). Similar outcomes were observed after six months of the therapy, except gender was replaced by etiologies of hyperthyroidism (p=0.009).

Conclusion: Radioactive iodine (131-I) therapy is effective for the treatment of hyperthyroidism. However, the appropriate dose is still debatable, as there was a high incidence of hypothyroidism post-therapy.

doi: https://doi.org/10.12669/pjms.39.6.7567

How to cite this: Khan MSA, Hussain A, Ahmad S, Shah MH. Outcomes of Radioactive Iodine (131I) Therapy among Hyperthyroid patients. Pak J Med Sci. 2023;39(6):1685-1689. doi: https://doi.org/10.12669/pjms.39.6.7567

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to Cite
Sajjad Ali Khan, M., Hussain, A., Ahmad, S., & Shah, M. H. (2023). Outcomes of Radioactive Iodine (131I) Therapy among Hyperthyroid patients. Pakistan Journal of Medical Sciences, 39(6). https://doi.org/10.12669/pjms.39.6.7567
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