Lamotrigine-associated toxic epidermal necrolysis

  • Omair Farooq
  • Akifa Abbas
  • Muhammad Ahmad
  • Abu Bakr Manzoor
Keywords: Toxic epidermal necrolysis, Bipolar disorder, Lamotrigine


Toxic Epidermal Necrolysis (TEN) is an uncommon, idiosyncratic, potentially fatal dermatologic emergency affecting skin and mucous membranes. It is characterized clinically by blistering and widespread exfoliation, and pathologically by apoptosis of keratinocytes and epidermal necrosis. Drugs are one of the most common causative agents. The management ranges from nutritional support, care of denuded skin and mucosa to intravenous immunoglobulins (IVIG). The patient being reported developed TEN, secondary to lamotrigine; an anti-epileptic drug also used for bipolar disorder. On admission, lamotrigine was discontinued, he was managed symptomatically and given IVIG for three days. His condition started to improve after the first dose and he got discharged on 6th day of admission.


How to cite this: Farooq O, Abbas A, Ahmad M, Manzoor AB. Lamotrigine-associated toxic epidermal necrolysis. Pak J Med Sci. 2023;39(6):1883-1886. doi:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to Cite
Farooq, O., Abbas, A., Ahmad, M., & Manzoor, A. B. (2023). Lamotrigine-associated toxic epidermal necrolysis. Pakistan Journal of Medical Sciences, 39(6).

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