Value of Cardiac Troponin, Myoglobin Combined with Heart-type Fatty Acid-binding Protein Detection in Diagnosis of Early Acute Myocardial Infarction

  • Jian-hua Sun
  • Xiao-kun Liu
  • Xiao-wei Xing
  • Yang Yang
  • Hui-hong Xuan
  • Bin-bin Fu
Keywords: Ctn, Myo, H-FABP, Combined detection, Acute myocardial infarction, Diagnosis

Abstract

Objective: To evaluate the value of cardiac troponin(cTn), myoglobin(Myo) combined with heart-type fatty acid-binding protein(H-FABP) detection in the diagnosis of early acute myocardial infarction(AMI).

Methods: This study was a clinical comparative study. Eighty patients with AMI hospitalized in Tangshan Workers’ Hospital were selected as study group, and another 80 individuals receiving normal physical examination were selected as control group from September 20, 2021 to September 20, 2022. The concentrations of cTn, Myo and H-FABPP, diagnostic indicators, the sensitivity and specificity of combined diagnosis, as well as the diagnostic efficacy for AMI were compared between the two groups.

Results: The levels of cTn, Myo and H-FABPP in the study group were significantly higher than those in the control group(P= 0.00). Multivariate logistic regression analysis showed that cTn, Myo and H-FABP were all relevant indicators for AMI. H-FABP alone has better diagnostic efficacy for AMI. The area under the curve of their combined detection, the specificity, and the sensitivity were higher than those of cTn, Myo and H-FABP alone, indicating that their combined application has the best diagnostic efficiency. cTn, Myo and H-FABP levels were positively correlated with Glu, TC, LDL-C and hs-CRP levels(P< 0.01), while negatively correlated with HDL level(P< 0.01).

Conclusions: The combined detection of cardiac markers such as cTn, Myo and H-FABP presents higher sensitivity and specificity in the diagnosis of AMI compared with any single detection, and can provide better data support for the definite diagnosis of AMI, with high clinical application value.

doi: https://doi.org/10.12669/pjms.39.6.7101

How to cite this: Sun J, Liu X, Xing X, Yang Y, Xuan H, Fu B. Value of Cardiac Troponin, Myoglobin Combined with Heart-type Fatty Acid-binding Protein Detection in Diagnosis of Early Acute Myocardial Infarction. Pak J Med Sci. 2023;39(6):1690-1694.  doi: https://doi.org/10.12669/pjms.39.6.7101

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2023-09-22
How to Cite
Sun, J.- hua, Liu, X.- kun, Xing, X.- wei, Yang, Y., Xuan, H.- hong, & Fu, B.- bin. (2023). Value of Cardiac Troponin, Myoglobin Combined with Heart-type Fatty Acid-binding Protein Detection in Diagnosis of Early Acute Myocardial Infarction. Pakistan Journal of Medical Sciences, 39(6). https://doi.org/10.12669/pjms.39.6.7101
Section
Original Articles