Hematological findings in COVID-19 and their correlation with severity of Disease

  • Namra Mahmood Central Park Medical College
  • Zahra Riaz Central Park medical college, Lahore.
  • Arooj Sattar Central Park Medical College, Lahore.
  • Mehwish Kiran Central Park Medical College, Lahore.
Keywords: COVID-19, Severity, Hematological parameters, Neutrophil lymphocyte ratio, Total leukocyte count, Total white cell count, Absolute neutrophil count, Lymphocyte count, Platelet count, PT, APTT, Length of hospital stay

Abstract

Objective: To evaluate the efficacy of hematological parameters to predict severity of COVID-19 patients.

Method: This was a cross-sectional comparative study conducted at Central Park Teaching Hospital, Lahore in COVID ward and COVID ICU between April 23, 2021 to June 23, 2021. Patients of all ages and both genders with positive PCR admitted in the COVID ward and ICU during this time span of two months were included in the study. Data was collected retrospectively.

Results: This study included 50 patients with male to female ratio of 1.38:1. Though males are more affected by COVID-19 but the difference is not statistically significant. The mean age of the study population was 56.21 and the patients in the severe disease group have higher age. It was observed that in severe/critical group the mean values of total leukocyte count 21.76×103 µI (p-value= 0.002), absolute neutrophil count 71.37% (p-value=0.045), neutrophil lymphocyte ratio (NLR) 12.80 (p-value=0.00) and PT 11.9 seconds (p-value=0.034) and the difference was statistically significant. While in severe/critical group, the mean values of hemoglobin 12.03g/dl (p-value=0.075), lymphocyte count 28.41% (p-value=0.8), platelet count 226×103 µI (p-value=0.67) and APTT 30.7 (p-value=0.081) and the difference was not significantly different between groups.

Conclusion: It can be concluded from the study that total leucocyte count, absolute neutrophil count and neutrophil lymphocyte ratio can predict in-hospital mortality and morbidity in COVID-19 patients.

doi: https://doi.org/10.12669/pjms.39.3.6836

How to cite this: Mahmood N, Riaz Z, Sattar A, Kiran M. Hematological findings in COVID-19 and their correlation with severity of Disease. Pak J Med Sci. 2023;39(3):795-798. doi: https://doi.org/10.12669/pjms.39.3.6836

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Namra Mahmood, Central Park Medical College

Assistant Professor, Pathology.

Zahra Riaz, Central Park medical college, Lahore.

Senior Demonstrator, Department of Pathology, 

Arooj Sattar, Central Park Medical College, Lahore.

Assistant Professor Pathology

Mehwish Kiran, Central Park Medical College, Lahore.

Senior Registrar Pulmonology 

Published
2023-03-27
How to Cite
Mahmood, N., Riaz, Z., Sattar, A., & Kiran, M. (2023). Hematological findings in COVID-19 and their correlation with severity of Disease. Pakistan Journal of Medical Sciences, 39(3). https://doi.org/10.12669/pjms.39.3.6836
Section
Original Articles