Changes in serum lipids with the onset and progression of Diabetic Retinopathy in Type-II Diabetes Mellitus

  • Mehnaz Nuruddin Gitay Dow University of Health Sciences
  • Arisha Sohail Department of Biochemistry, Dow University of Health Science, Karachi, Pakistan.
  • Yasmeen Arzoo Institute of Basic Medical Sciences, Dow University of Health Science, Karachi, Pakistan
  • Muhammad Ali Shakir
Keywords: Diabetic Retinopathy, Dyslipidemia, Type 2 Diabetes Mellitus

Abstract

Objective: To investigate the role of serum lipids in the onset and progression of Diabetic Retinopathy (DR) in Type-II diabetes (T2DM) individuals.

Methods: This cross-sectional study was conducted at the National Institute of Diabetes and Endocrinology (NIDE), Dow University of Health Sciences (DUHS) from March to May 2019. After signing the informed consent, healthy controls (n=30), T2DM patients (diabetic n=30), proliferative (PDR n=30) and non-proliferative (NPDR n= 30) of age 18 to 65 years were selected by convenient sampling. Background information was gathered through interviews and the fundoscopy was done. Fasting five ml venous blood samples were collected and analysed for triglycerides (TGs), cholesterol, HDL, LDL, VLDL and the HbA1c using commercially available assays. The SPSS, version 24.0, was used for data analysis.

Results: The HbA1c level was high in the diabetes, NPDR and PDR groups than control (p<0.05). The serum TGs and cholesterol were raised while the HDL was low in the diabetes group than in control (p<0.05). The cholesterol and LDL were high in the diabetes group compared to NPDR and PDR groups (p<0.05). The cholesterol and VLDL showed a positive moderately strong correlation with HbA1c in the PDR group (p<0.05).

Conclusion: The serum lipid levels vary with the HbA1c levels and greater degree of derangement is observed with increasing mean HbA1C independent of diabetic retinopathy. For this reason, strict control of HbA1c and serum lipid level by lifestyle and/or pharmacologic intervention is recommended in diabetes with or without retinopathy.

doi: https://doi.org/10.12669/pjms.39.1.6265

How to cite this: Gitay MN, Sohail A, Arzoo Y, Shakir MA. Changes in serum lipids with the onset and progression of Diabetic Retinopathy in Type-II Diabetes Mellitus. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.6265

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biography

Arisha Sohail, Department of Biochemistry, Dow University of Health Science, Karachi, Pakistan.

Department of Biochemistry,

Dow University of Health Science, Karachi, Pakistan.

Published
2022-11-16
How to Cite
Gitay, M. N., Sohail, A., Arzoo, Y., & Shakir, M. A. (2022). Changes in serum lipids with the onset and progression of Diabetic Retinopathy in Type-II Diabetes Mellitus. Pakistan Journal of Medical Sciences, 39(1). https://doi.org/10.12669/pjms.39.1.6265