Cardio protective effect of nicorandil in reperfusion injury among patients undergoing primary percutaneous coronary intervention

  • Maria Ilyas National university of medical sciences
  • Dr. Mudassar Noor National University Of Medical Sciences
  • Dr. Hamid Sharif Khan Rawalpindi Institute of Cardiology
  • Dr. Sauleha Haroon Rawalpindi Institute of Cardiology
  • Dr. Kulsoom Farhat National University Of Medical Sciences
  • Dr. Shabana Ali National University Of Medical Sciences
Keywords: Nicorandil, Percutaneous coronary intervention, Myocardial reperfusion injury, Cardio protective agents

Abstract

Objectives: To evaluate the effect of nicorandil in prevention of reperfusion injury during primary percutaneous coronary intervention by thrombolysis in myocardial infarction flow grade scoring.

Methods: A total of 140 patients from Rawalpindi Institute of Cardiology were enrolled in this study conducted from 7th September to 10th of October 2021. These participants were allocated into two major groups. Control group received conventional acute coronary syndrome protocol regimen only whereas experimental group was given nicorandil along with conventional acute coronary syndrome protocol. During primary percutaneous coronary intervention, thrombolysis in myocardial infarction flow grade scoring was analyzed and compared.

Results: Majority of participants in nicorandil group achieved thrombolysis in myocardial infarction Grade-3 scoring which indicated reduced rate of no reflow phenomenon as compared to control group. A statistically significant difference was noted in score of both groups (p value = 0.001) signifying prophylactic use of nicorandil before primary percutaneous coronary intervention along with conventional acute coronary syndrome protocol is superior to only conventional acute coronary syndrome protocol regimen to cases in the control group.

Conclusion: Use of nicorandil in ST elevated myocardial infarction patients before primary percutaneous coronary intervention prevents reperfusion injury thus decreasing the risk of post percutaneous coronary intervention complications and reducing mortality rate in cardiac patients suggesting its significant cardio protective role.

doi: https://doi.org/10.12669/pjms.39.1.6034

How to cite this: Ilyas M, Noor M, Khan HS, Haroon S, Farhat K, Ali S. Cardio protective effect of nicorandil in reperfusion injury among patients undergoing primary percutaneous coronary intervention. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.6034

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Dr. Mudassar Noor, National University Of Medical Sciences

Assistant professor of Pharmacology

Army Medical College Rawalpindi

Dr. Hamid Sharif Khan, Rawalpindi Institute of Cardiology

Assistant professor of Cardiology

Rawalpindi Institute of Cardiology

Dr. Sauleha Haroon, Rawalpindi Institute of Cardiology

Senior Registrar of Cardiology

Rawalpindi Institute of Cardiology

Dr. Kulsoom Farhat, National University Of Medical Sciences

Professor of Pharmacology

Army medical college Rawalpindi

Dr. Shabana Ali, National University Of Medical Sciences

Assistant Professor of Pharmacology

Army medical college Rawalpindi

Published
2022-11-12
How to Cite
Ilyas, M., Dr. Mudassar Noor, Dr. Hamid Sharif Khan, Dr. Sauleha Haroon, Dr. Kulsoom Farhat, & Dr. Shabana Ali. (2022). Cardio protective effect of nicorandil in reperfusion injury among patients undergoing primary percutaneous coronary intervention. Pakistan Journal of Medical Sciences, 39(1). https://doi.org/10.12669/pjms.39.1.6034