Correlation of Serum Vaspin, Omentin-1, and adiponectin with metabolic phenotypes in Type-2 diabetes mellitus patients

Adipocytokines and T2DM

  • Mukhtiar Baig, Prof Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia
  • Zohair J Gazzaz, Dr Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia
  • Marwan A Bakarman, Prof Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia
  • Sami H Alzahrani, Dr Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
Keywords: Diabetes Mellitus; Adipokines; Vaspin; Omentin-1; Adiponectin

Abstract

Objectives: To investigate adipocytokines’ (vaspin, omentin-1, and adiponectin) correlation with metabolic phenotypes in type 2 diabetes mellitus (T2DM) patients. 

Methods: This case-control research was done at the Diabetic Clinic in Jeddah, Kingdom of Saudi Arabia (KSA), from November 2018 to March 2019. Seventy-five T2DM patients and 75 gender, age, and BMI-matched healthy subjects were recruited for this research. 

Results: In DM patients, the concentrations of serum vaspin and omentin-1 were substantially lower (p<0.001) than in the control group. A significant positive relationship between vaspin concentration and DBP (p<0.001), BMI (p<0.001), and waist circumference (p<0.001) was found in patients and control subjects, while FPG (p<0.016), serum insulin (p<0.001), HOMA-IR (p<0.001), TC (p<0.001), TG (p<0.001), and LDLc (p<0.001) were significantly interrelated among patients. Serum concentrations of omentin-1 and ADN were significantly negatively correlated with serum insulin, HOMA-IR, and TG among the DM group. Serum vaspin and ADN levels were significantly higher in the cases and control groups with BMI>25, and no gender-wise variance was observed in adipocytokines levels. Binary logistic regression analysis showed a significantly negative predictive relationship of vaspin and omentin-1 with DM.

Conclusion: The DM group displayed substantially lower serum vaspin and omentin-1 levels. However, there was no consistent relationship observed between these adipocytokines and metabolic phenotypes.

doi: https://doi.org/10.12669/pjms.37.7.4330

How to cite this:
Baig M, Gazzaz ZJ, Bakarman MA, Alzahrani SH. Correlation of Serum Vaspin, Omentin-1, and adiponectin with metabolic phenotypes in Type-2 diabetes mellitus patients. Pak J Med Sci. 2021;37(7):1762-1767.   doi: https://doi.org/10.12669/pjms.37.7.4330

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Mukhtiar Baig, Prof, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia

Professor, Department of Clinical Biochemistry

Zohair J Gazzaz, Dr, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia

Associate professor, Department of internal medicine

Marwan A Bakarman, Prof, Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia

Professor, Department of Family and Community Medicine,

Sami H Alzahrani, Dr, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia

Assistant Professor, Department of Family Medicine

Published
2021-10-05
How to Cite
Baig, M., Gazzaz, Z., Bakarman, M., & Alzahrani, S. (2021). Correlation of Serum Vaspin, Omentin-1, and adiponectin with metabolic phenotypes in Type-2 diabetes mellitus patients. Pakistan Journal of Medical Sciences, 37(7). https://doi.org/10.12669/pjms.37.7.4330
Section
Original Articles