Correlations of circulating miR-26b level with left ventricular hypertrophy and cardiac function in elderly patients with hypertension

Jian Fu; Fang Lin; Zhengxia Pan; Chun Wu

doi:10.12669/pjms.37.4.4048

Jian Fu
Fang Lin
Zhengxia Pan Children's Hospital of Chongqing Medical University
Chun Wu

DOI: https://doi.org/10.12669/pjms.37.4.4048

Keywords: miR-26b; Elderly; Hypertension; Left ventricular hypertrophy; Cardiac function

Abstract

Objectives: To study the correlations of circulating miR-26b level with left ventricular hypertrophy (LVH) and cardiac function in elderly patients with hypertension.

Methods: A total of 132 eligible patients were divided into low and high miR-26b level groups. Their baseline clinical data and biochemical indices were compared. The correlations between miR-26b level and echocardiographic parameters were studied by Pearson’s analysis. Factors affecting LVH were explored by multivariate logistic regression analysis. The role of miR-26b in diagnosing LVH was predicted by receiver operating characteristic curve.

Results: The relative expression level of miR-26b was 4.56-16.93, with a median of 7.62. The two groups had similar baseline clinical data and biochemical indices (P>0.05). Compared with high miR-26b level group, interventricular septal thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular mass index (LVMI) and number of LVH cases in low miR-26b level group significantly increased (P<0.05), and mitral ratio of peak early to late diastolic filling velocity (E/A) decreased (P<0.05). Circulating miR-26b level was negatively correlated with IVST, LVPWT and LVMI (P<0.0001), and positively correlated with E/A (P<0.0001). The proportion of cardiac hypofunction cases in low miR-26b level group significantly exceeded that of high miR-26b level group (P<0.05). Age and increased IVST, LVPWT and LVMI were independent risk factors for LVH (P<0.05), and elevated miR-26b level was a protective factor (P<0.05). AUC was 0.836, and the optimal cutoff value was 8.83, with high sensitivity and specificity.

Conclusions: MiR-26b level is negatively correlated with LVH and positively correlated with left ventricular diastolic function in elderly hypertensive patients. It is a protective factor for LVH complicated with diastolic dysfunction and a potential biomarker for diagnosis.

doi: https://doi.org/10.12669/pjms.37.4.4048

How to cite this:
Fu J, Lin F, Pan Z, Wu C. Correlations of circulating miR-26b level with left ventricular hypertrophy and cardiac function in elderly patients with hypertension. Pak J Med Sci. 2021;37(4):966-971. doi: https://doi.org/10.12669/pjms.37.4.4048

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.