Emerging Anti-Microbial Resistance in Febrile Neutropenia: Is it high time to evaluate quality control measures?

  • Uzma Mahar
  • Nida Anwar National Institte of Blood Diseases and Bone Marrow Transplantation
  • Naveena Fatima
  • Jawad Hassan
  • Tahir Shamsi
Keywords: Anti-Microbial Resistance, Febrile Neutropenia, Quality Control

Abstract

Objective: We performed a prospective analysis at our center to find out the most common organisms causing bacterial infections to establish pattern of antibiotic resistance, in order to combat febrile neutropenia effectively in the terms of outcome as well as cost.

Methods: A hospital based observational study was conducted at National Institute of Blood Diseases and bone marrow transplantation from January 2017 to December 2017. Patients presented with absolute neutrophil count (ANC) of less than 500/ml were enrolled. Data were analyzed by SPSS version 21.0. P-value of <0.05 was considered statistically significant.

Results: In this study, a total of 242 patients from various hematological disorders were enrolled and 403 bacterial isolates were obtained. The most frequent isolated gram-negative organisms were Escherichia coli, followed by Klebsiella pneumoniae and the most prevalent gram-positive organisms were staphylococcus aureus and Enterococcus species. The antimicrobial susceptibility testing revealed that most of the Staphylococcus aureus isolates were highly resistant to methicillin (p = 0.002), whereas Enterococcus species were resistant to vancomycin (p = 0.000).

Conclusion: The choice of empirical antibiotic regimen should be based on local spectrum of bacteria and their regional susceptibility pattern to improve the survival and minimize hospital stay of patients.

doi: https://doi.org/10.12669/pjms.36.6.2138

How to cite this:
Mahar U, Anwar N, Fatima N, Hassan J, Shamsi T. Emerging Anti-Microbial Resistance in Febrile Neutropenia: Is it high time to evaluate quality control measures? Pak J Med Sci. 2020;36(6):1246-1251. doi: https://doi.org/10.12669/pjms.36.6.2138

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2020-08-19
How to Cite
Mahar, U., Anwar, N., Fatima, N., Hassan, J., & Shamsi, T. (2020). Emerging Anti-Microbial Resistance in Febrile Neutropenia: Is it high time to evaluate quality control measures?. Pakistan Journal of Medical Sciences, 36(6). https://doi.org/10.12669/pjms.36.6.2138
Section
Original Articles