Exploring the significance of GNG11, LPAR1, and AGTR1 in early diagnosis and prognosis of cervical cancer: A correlative analysis with clinical characteristics

Abstract

Objective: To investigate the significance of G-protein gamma subunit 11 (GNG11) expression in the diagnosis and prognosis of cervical cancer (CC).

Methodology: This was a retrospective study. Differentially expressed genes in CC were retrieved from the Gene Expression Omnibus (GEO). A cohort of 68 CC patients from General Hospital of Ningxia Medical University Cancer Hospital was enrolled in the study from March 2021 to March 2024. Immunohistochemistry was employed to evaluate the expression levels of G-protein subunit γ 11 (GNG11), lysophospholipid receptor 1 (LPAR1), and angiotensin II receptor 1 (AGTR1) in cancerous and pericancerous tissues of CC patients. The correlations between the positive expressions of GNG11, LPAR1, or AGTR1 and the clinicopathological parameters of CC patients were analyzed.

Results: A significant correlation was observed between low positive expression of GNG11 and tumor size (P=0.0068), FIGO stage (P=0.0282), and lymph node metastasis (P=0.0101) in CC patients. Similarly, low positive expression of LPAR1 was correlated with FIGO stage (P=0.0024) and lymph node metastasis (P=0.0203). Patients exhibiting high positive expression of GNG11 demonstrated prolonged OS (P=0.0001) and RFS (P=0.0422) compared to those with low expression. Cox regression analysis revealed that FIGO stage (P=0.014), lymph node metastasis (P=0.002), and GNG11 expression (P=0.026) emerged as independent prognostic indicators for OS in CC patients.

Conclusion: The positive expression level of GNG11 is intricately linked to the early diagnosis and prognosis of CC, underscoring its potential as a significant diagnostic and prognostic indicator.