TY - JOUR AU - Ejaz, Hasan PY - 2019/10/09 Y2 - 2024/03/29 TI - Emerging resistance of van genotype in enterococci: A potential menace for therapeutic failure: Emerging van genotype in enterococci JF - Pakistan Journal of Medical Sciences JA - Pak J Med Sci VL - 35 IS - 6 SE - Original Articles DO - 10.12669/pjms.35.6.1145 UR - https://pjms.org.pk/index.php/pjms/article/view/1145 SP - AB - Objectives: Emerging cases of vancomycin-resistant enterococci (VRE) are detrimental for the patients. The current study aimed to ascertain the occurrence of VRE, their antibiogram and the van genotype responsible for vancomycin resistance.Methods: A total number of 2,958 clinical specimens were processed at Microbiology Department of the Alrazi Health Care, Lahore during the one year (2016-2017) using microbiological culture media, biochemical and serology. Antibiogram of enterococcal strains was performed using disc diffusion and E-test. ATCC Enterococcus faecalis 29212 was used as a quality control strain. The detection of van genotypes was accomplished by multiplex PCR assay.Results: Out of the 147 enterococci, 139 (94.6%) were E. faecalis, and 8 (5.4%) were E. faecium. Statistically significant associations of urine (p < 0.001), pus (p < 0.001) and wound swabs (p = 0.001) were observed with E. faecalis. A significant correlation of enterococcal infections (p = 0.05) was seen with female patients. Four (2.9%) strains of E. faecalis found to be VRE with vanB (75%) and vanA (25%) genotypes.Conclusion: The emerging strains of VRE (vanB and vanA genotype) in the current study are a potential menace for therapeutic failure, which left the physicians with only linezolid as a therapeutic option.doi: https://doi.org/10.12669/pjms.35.6.1145How to cite this:Ejaz H. Emerging resistance of van genotype in enterococci: A potential menace for therapeutic failure. Pak J Med Sci. 2019;35(6):1659-1663. doi: https://doi.org/10.12669/pjms.35.6.1145This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ER -