@article{Sun_Gao_Li_Li_2021, title={Observations on the clinical efficacy of rhaFGF combined with Vitamin B complex for patients with Severe Recurrent Aphthous Ulcer: Treatment of severe recurrent aphthous ulcerĀ (RAU)}, volume={37}, url={https://pjms.org.pk/index.php/pjms/article/view/4364}, DOI={10.12669/pjms.37.7.4364}, abstractNote={<p><em><strong>Objectives:</strong></em> To observe the therapeutic effect of rha FGF combined with vitamin B complex on severe recurrent aphthous ulcers&nbsp;(RAUs).</p> <p><em><strong>Methods:</strong></em> Ninety patients with severe RAU (grade III and IV) admitted to Chinese PLA General Hospital from May 2018 to May 2019 were selected and divided into two groups using a random number table, 45 patients/group. Patients in the control group gargled with a mixture of vitamin B complex (250 ml of 9% normal saline +250 ml of vitamin B complex +160,000 U of gentamicin +25 ml of lidocaine) after oral cleaning; patients in the observation group gargled with a mixture of the same ratio after oral cleaning and then sprayed rhaFGF on their oral ulcers. The clinical symptoms and treatment effects of the 2 groups within 1 week of medication were compared.</p> <p><em><strong>Results:</strong></em> The total effective rate of treatment was 97.78% in the observation group and 82.22% in the control group; the difference was statistically significant (P &lt;0.05). The time to ulcer pain disappearance and eating recovery and the ulcer healing time in the observation group were significantly shorter than those in the control group (P &lt;0.05).</p> <p><em><strong>Conclusion:</strong></em> rhaFGF combined with vitamin B complex has a significant therapeutic effect for patients with severe RAU; it can relieve pain and illness faster and shorten the healing time of ulcers.</p> <p><strong>doi: https://doi.org/10.12669/pjms.37.7.4364</strong></p> <p><em><strong>How to cite this:</strong></em><br>Sun H, Gao J, Li D, Li B. Observations on the clinical efficacy of rhaFGF combined with Vitamin B complex for patients with Severe Recurrent Aphthous Ulcer. Pak J Med Sci. 2021;37(7):2004-2007. doi: https://doi.org/10.12669/pjms.37.7.4364</p> <p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p&gt;}, number={7}, journal={Pakistan Journal of Medical Sciences}, author={Sun, Hui and Gao, Jie and Li, Dan and Li, Bing}, year={2021}, month={Oct.} }