@article{Dobrosavljevic_Rakic_Mihajlovic_2019, title={Risk of spontaneous preterm labor in pregnancies achieved by in vitro fertilization and complicated with severe form of ovarian hyperstimulation syndrome: A case control study: Severe OHSS and preterm birth}, volume={35}, url={https://pjms.org.pk/index.php/pjms/article/view/145}, DOI={10.12669/pjms.35.4.145}, abstractNote={<p><em><strong>Objectives:</strong></em> The purpose of this study was to examine the potential impact of severe Ovarian hyper stimulation syndrome (OHSS) on the risk of preterm birth. Severe ovarian hyperstimulation syndrome is a serious complication in the methods of in vitro fertilization. The pathophysiology of this process is not clear enough and the treatment is symptomatic. Human chorionic gonadotropin (h-CG) is the most important known cause of this condition. Findings of other authors often do not match when it comes to complications that may occur in pregnancy.</p> <p><em><strong>Methods:</strong> </em>In the Gynecology and Obstetrics Clinic “Narodni Front” a case control study was conducted on 50 female patients with severe forms of OHSS in the period from January 2008 to March 2015. A control group was created based on age and it involved 59 patients with pregnancy achieved with IVF/ICSI during the same period, but in which OHSS did not occur.</p> <p><em><strong>Results:</strong></em> Patients with the pregnancy complicated by OHSS, had a considerably higher rate of preterm labor, whether this was labor before gestation week 37 (56.0% vs. 30.5%) or before gestation week 34 (34.0% vs. 6.8%); significantly lower weight of newborns, as in the newborns with low body weight &lt;2500g (45.6% vs. 25.0%) and specially in the newborn with very low body weight &lt;1500 grams (19.1% vs. 3.8%), as well as preterm premature rupture of membranes (PPROM), (11.76% vs. 1.59%).</p> <p><em><strong>Conclusions:</strong></em> Pregnancy achieved by the IVF/ICSI method in which severe form of OHSS has been developed could have an increased risk of preterm birth.</p> <p><strong>doi: https://doi.org/10.12669/pjms.35.4.145</strong></p> <p><em><strong>How to cite this:</strong></em><br>Dobrosavljevic A, Rakic S, Mihajlovic S. Risk of spontaneous preterm labor in pregnancies achieved by in vitro fertilization and complicated with severe form of ovarian hyperstimulation syndrome: A case control study. Pak J Med Sci. 2019;35(4):923-928.&nbsp;&nbsp;doi: https://doi.org/10.12669/pjms.35.4.145</p> <p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p&gt;}, number={4}, journal={Pakistan Journal of Medical Sciences}, author={Dobrosavljevic, Aleksandar and Rakic, Snezana and Mihajlovic, Sladjana}, year={2019}, month={Jul.} }