Factors affecting the outcome of hospitalization among liver cirrhosis patients

Outcome of hospitalization among liver cirrhosis patients

  • Yasir Mahmud Consultant
  • Muhamamd Irfan Associate Professor of Medicine, Gujranwala Medical College/Teaching Hospital, Gujranwala, Pakistan
  • Rana Muhammad Suhail Khan Senior Registrar, Allama Iqbal Medical College / Jinnah hospital, Lahore, Pakistan
  • Qamar Rafiqa Assistant Professor, Gujranwala Medical College/Teaching Hospital, Gujranwala, Pakistan
  • Muhammad Arif Nadeem Professor of Medicine, Services Institute of Medical Sciences / Services Hospital, Lahore, Pakistan
  • Aftab Mohsin Professor of Medicine, Allama Iqbal Medical College / Jinnah hospital, Lahore, Pakistan
Keywords: Liver cirrhosis, Outcome of hospitalization, Pulmonary aspiration, Age groups, SPSS

Abstract

Objectives: To determine the factors affecting the outcome of hospitalization in patients suffering liver cirrhosis hospitalized to tertiary care hospital, Gujranwala, Pakistan.

Methods: After informed consent, the data of liver cirrhosis patients with age >12 years hospitalized from June 2016 to May 2017 was collected by purposive sampling. The outcome of the hospitalization in term of ‘death’ and ‘no death’ was noted. Statistical analysis was done using SPSS version 25. Bivariate analysis as well binary logistic regression was performed to ascertain the effect of different predictors like gender, age, history of diabetes mellitus, etiology of cirrhosis, presence of hepatic encephalopathy at presentation, presence of upper GI bleed, and tracheobronchial aspiration on the likelihood that death would be the outcome in liver cirrhosis patients.

Results: Amongst total of 1304 patients, 15.7% died during hospitalization. The mean age of those who died was 58.08 + 14.49 years. Bivariate analysis suggested that mortality was significantly higher in group of patients who had hepatic encephalopathy at presentation (p<0.01), no upper gi bleed (p<0.01), and who got tracheobronchial aspiration during hospitalization (p<0.01). It did not differ significantly in male/female gender (p=0.504), diabetic/non-diabetic groups (p=0.652), with viral/non-viral etiology of cirrhosis (p=0.918). Binary logistic regression revealed that patients who had tracheobronchial aspiration were 12.392 times more likely to die than who had no tracheobronchial aspiration. Similarly, patients who presented in hepatic encephalopathy were 7.862 times more likely to die than who presented without hepatic encephalopathy.

Conclusion: The inpatient mortality rate amongst cirrhotic patients was high. Age, gender, history of diabetes, viral etiology of cirrhosis did not significantly contribute in the mortality of these patients. The patients who presented in hepatic encephalopathy, and who suffered tracheobronchial aspiration during hospitalization were more likely to die. Excellence in hepatic encephalopathy management and prevention from aspiration can effectively reduce the mortality rate of cirrhotic patients in our hospitals.

doi: https://doi.org/10.12669/pjms.35.5.884

How to cite this:
Irfan M, Mahmud Y, Khan RMS, Rafiq Q, Nadeem MA, Mohsin A. Factors affecting the outcome of hospitalization among liver cirrhosis patients. Pak J Med Sci. 2019;35(5):1382-1386. doi: https://doi.org/10.12669/pjms.35.5.884

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biography

Muhammad Arif Nadeem, Professor of Medicine, Services Institute of Medical Sciences / Services Hospital, Lahore, Pakistan

Professor of Medicine & Gastroenterology at Services Institute of Medical Sciences Lahore 

Published
2019-08-22
Section
Original Articles