Relationship between Monoclonal Gammopathy of undetermined significance and multiple myeloma via online database analysis

  • Weiguo Lu
  • Jiaming Liu
  • Man Luo
  • Mingfeng Xiao
Keywords: Multiple Myeloma (MM), Monoclonal Gammopathy of Undetermined Significance (MGUS), Bioinformatics, PI3K/AKT/mTOR, Inflammation, Immune dysfunction

Abstract

Objective: To explore the relationship between Monoclonal Gammopathy of undetermined significance (MGUS) and Multiple Myeloma (MM) based on bioinformatics methods.

Methods: In this study, we conducted bioinformatics to identify genes associated with MGUS and MM using the PubMed pubmed2ensemble (http://pubmed2ensembl.ls.manchester. ac.uk/) until 2021. Gene ontology function was used to label overlapping genes, and Kyoto Encyclopedia of Genes and Genomes analysis was used to identify enriched pathways. The cluster-1 genes obtained from Cytoscape were analyzed by Comparative Toxicogenomics Database (CTD, http://ctdbase.org/) and then used to screen candidate drugs using the DSigDB database (https://amp.pharm.mssm.edu/Enrichr/).

Results: In total, 227 genes were common to both MGUS and MM. These genes were significantly associated with cytokine-cytokine receptor interaction and the PI3K-Akt signaling pathway. The protein-protein interaction network revealed that TNF, IL-1B, IL-6, CSF2, CXCL8, and IL-10 were among the core genes of MM. Finally, eight candidate drugs showed maximum interaction with core genes, which could potentially prevent MGUS from progressing to MM.

Conclusion: The progression of MGUS to MM is driven by aberrant cytokine secretion, which leads to inflammation immune dysfunction, and dysregulation of the PI3K/AKT/mTOR signaling pathway.

doi: https://doi.org/10.12669/pjms.39.3.7206

How to cite this: Lu W, Liu J, Luo M, Xiao M. Relationship between Monoclonal Gammopathy of undetermined significance and multiple myeloma via online database analysis. Pak J Med Sci. 2023;39(3):715-720. doi: https://doi.org/10.12669/pjms.39.3.7206

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2023-03-27
How to Cite
Lu, W., Liu, J., Luo, M., & Xiao, M. (2023). Relationship between Monoclonal Gammopathy of undetermined significance and multiple myeloma via online database analysis. Pakistan Journal of Medical Sciences, 39(3). https://doi.org/10.12669/pjms.39.3.7206
Section
Original Articles