Spectrum of preneoplastic and Neoplastic lesions of intestine in a tertiary care hospital of Karachi, Pakistan

Preneoplastic & neoplastic lesions of intestine in Karachi

  • Asma Shabbir Jinnah Sindh Medical University
  • Muhammad Asif Qureshi Dow University of Health Sciences
  • Saadia Akram
  • Talat Mirza
Keywords: Squamous cell carcinoma, Adenocarcinoma, Adenoma, Preneoplastic, Neoplastic

Abstract

Objectives: To present 7 years data mentioning the spectrum of preneoplastic & neoplastic cases of intestine received at Dow Diagnostic Research and Reference Laboratory.

Methods: All the cases of preneoplastic & neoplastic lesions of intestine received during 2009 – 2015 were reviewed. The data obtained were subjected to descriptive statistical analysis using SPSS version 22. Furthermore, the association of diagnosis was seen with various other variables including age, gender & site of the lesion. A p-value of < 0.05 was considered as significant.

Results: The total samples were 486, out of which 33 cases were of premalignant and 453 were of malignant lesions. Out of total 33 cases of premalignant lesions of intestine, it consisted adenomatous polyp = 39.4% (n=13), dysplasia = 36.4% (n=12) and adenoma = 24.2% (n=8). From the total of 453 cases diagnosed as malignant lesions; adenocarcinoma as Grade-I were 14.2% (n=64), Grade-II were 7.6% (n=260) and Grade-III were 22% (n=99). Squamous cell carcinoma Grade-I were 0.4% (n=2), Grade-II 1.6% (n=7) and Grade-III 0.9% (n=4). 2.4% (n=11) cases were of metastatic adoncarcinoma, 0.9% (n=4) were diagnosed as neuroendocrine tumors and 0.4% (n=2) as lymphoma. A significant association was seen between site of the tumor and diagnosis, rectum was the commonest site for adenocarcinomas (p=0.001). Moderately differentiated adenocarcinoma was predominantly present in young age (p=0.001).

Conclusion: Colorectal carcinoma is on rise in Pakistan, predominantly in young males, and rectum being the commonest site. In our study, all the lesions showed male predominance with adenomatous polyp as the commonest premalignant lesion & Grade-II adenocarcinoma the most common malignancy of intestine.

doi: https://doi.org/10.12669/pjms.36.2.687

How to cite this:
Shabbir A, Qureshi MA, Akram S, Mirza T. Spectrum of preneoplastic and Neoplastic lesions of intestine in a tertiary care hospital of Karachi, Pakistan. Pak J Med Sci. 2020;36(2):75-79. doi: https://doi.org/10.12669/pjms.36.2.687

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Asma Shabbir, Jinnah Sindh Medical University

Department of Pathology

       Sindh Medical College

       Jinnah Sindh Medical University 

       Karachi - Pakistan

       E-mail: drasma52@gmail.com

       Phone: 03332128952

Muhammad Asif Qureshi, Dow University of Health Sciences

Associate 

      Associate Professor

     Dow International Medical College

     Dow University of Health Sciences

     Karachi-Pakistan

 

Saadia Akram

Professor

     Professor & Acting Registrar

    Department of Pathology

     Sindh Medical College

      Jinnah Sindh Medical University

      Karachi-Pakistan

      

 

Talat Mirza

Professor of Pathology & Head of Histopathology

     Dean of Research Department

     Dr. Ziauddin Hospital & University

     Karachi – Pakistan

Published
2019-12-14
How to Cite
Shabbir, A., Qureshi, M., Akram, S., & Mirza, T. (2019). Spectrum of preneoplastic and Neoplastic lesions of intestine in a tertiary care hospital of Karachi, Pakistan. Pakistan Journal of Medical Sciences, 36(2). https://doi.org/10.12669/pjms.36.2.687
Section
Original Articles