Correlation between serum SIRT1 and EZH2 expressions and peritoneal function in patients with diabetic nephropathy undergoing peritoneal dialysis

  • Qi Zhu
  • Haiyan Hu
  • Fang Xia Jingmen Hospital of Traditional Chinese Medinine
Keywords: Diabetic nephropathy, Silent information regulator 1, Zeste 2 polycomb repressive complex 2 subunit, Peritoneal function

Abstract

Objectives: To determine the correlation between the expression of silent information regulator 1 (SIRT1) and enhancer of zeste two polycomb repressive complex two subunit (EZH2) and peritoneal function in patients with diabetic nephropathy (DN) and peritoneal dialysis.

Methods: One hundred forty patients with DN underwent peritoneal dialysis in Hanchuan People’s Hospital from April 2016 to January 2019 were divided into four groups according to the duration of peritoneal dialysis. The levels of SIRT1 and EZH2 in serum were measured. The ratio of dialysate to plasma creatinine (D/Pcr) and the concentration of cancer antigen 125 (CA125) in peritoneal dialysate were determined. The ratio of urea clearance to urea distribution volume (Kt/V) of dialyzer was calculated. The correlations between SIRT1 and EZH2 expressions and peritoneal function were analyzed.

Results: With the prolongation of peritoneal dialysis, serum SIRT1 expression, Kt/V, Ccr and CA125 decreased, while EZH2 expression and D/Pcr increased in patients with DN undergoing peritoneal dialysis. Pearson’s correlation analysis showed that SIRT1 expression was negatively correlated with D/Pcr while positively correlated with Kt/V and CA125, and serum EZH2 expression was negatively correlated with Kt/V and CA125 while positively correlated with D/Pcr. ROC analysis demonstrated that SIRT1 and EZH2 expressions had certain diagnostic value for the poor prognosis of patients with DN undergoing peritoneal dialysis.

Conclusion: Serum SIRT1 and EZH2 expressions in patients with DN undergoing peritoneal dialysis are closely related to their peritoneal function. They have certain diagnostic value for the poor prognosis of patients with DN undergoing peritoneal dialysis.

doi: https://doi.org/10.12669/pjms.38.8.5527

How to cite this:
Zhu Q, Hu H, Xia F.Correlation between serum SIRT1 and EZH2 expressions and peritoneal function in patients with diabetic nephropathy undergoing peritoneal dialysis. Pak J Med Sci. 2022;38(8):---------.  doi: https://doi.org/10.12669/pjms.38.8.5527

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2022-09-16
How to Cite
Zhu, Q., Hu, H., & Xia, F. (2022). Correlation between serum SIRT1 and EZH2 expressions and peritoneal function in patients with diabetic nephropathy undergoing peritoneal dialysis. Pakistan Journal of Medical Sciences, 38(8). https://doi.org/10.12669/pjms.38.8.5527
Section
Original Articles