Value of combined detection of PCA, ANCA, ASCA, AGA and ANA in early diagnosis of Gastrointestinal Diseases

  • Xin Liu
  • Deli Guo
  • Xiaoyan Li
  • Yaping Guo Baoding NO.1 Central Hospital
  • Wenjie Song
Keywords: Anti-parietal cell antibody, Anti-neutrophil cytoplasmic antibody, Anti-Saccharomyces cerevisiae antibody, Anti-gliadin antibody; Anti-nuclear antibody

Abstract

Objectives: To investigate the positive detection rate and clinical application value of anti-parietal cell antibody (PCA), anti-neutrophil cytoplasmic antibody (ANCA), anti-Saccharomyces cerevisiae antibody (ASCA), anti-gliadin antibody (AGA) and anti-nuclear antibody (ANA) in patients visiting the Department of Gastroenterology.

Methods: From January 2015 to June 2018, 1,083 patients receiving detection of PCA and other autoantibodies were selected from the Department of Gastroenterology of Baoding First Central Hospital. The positive detection rate of autoantibodies was statistically analyzed. The enumeration data were expressed as rate or constituent ratio, and the rates were compared between groups using the x2 test.

Results: Among the 1,083 patients, the positive detection rate of ANA, ASCA, AGA, PCA and ANCA was 33.52%, 16.71%, 15.51%, 13.66% and 7.66%, respectively. The total positive detection rate was 62.8% (n = 680).

Conclusion: The population with abdominal distension, chronic abdominal pain, diarrhea and other digestive system symptoms should be timely treated with combined detection of PCA, ANCA, ASCA, AGA and ANA, which is of important clinical application value for early diagnosis of gastrointestinal diseases and prevention of missed diagnosis and misdiagnosis.

doi: https://doi.org/10.12669/pjms.38.1.4682

How to cite this:
Liu X, Guo D, Li X, Guo Y, Song W. Value of combined detection of PCA, ANCA, ASCA, AGA and ANA in early diagnosis of Gastrointestinal Diseases. Pak J Med Sci. 2022;38(1):227-231. doi: https://doi.org/10.12669/pjms.38.1.4682

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2021-11-22
How to Cite
Liu, X., Guo, D., Li, X., Guo, Y., & Song, W. (2021). Value of combined detection of PCA, ANCA, ASCA, AGA and ANA in early diagnosis of Gastrointestinal Diseases. Pakistan Journal of Medical Sciences, 38(1). https://doi.org/10.12669/pjms.38.1.4682
Section
Original Articles