Determination of serum tumor necrosis factor-alpha (TNF-α) levels in metabolic syndrome patients from Saudi population

Keywords: Metabolic syndrome, Inflammatory markers, Serum concentrations, TNF-α, Saudi population

Abstract

Objectives: To detect the relationship between serum tumor necrosis factor-alpha (TNF-α) and metabolic syndrome (MetS) components in patients of the Saudi population.

Methods: This cross-sectional study was carried out at Jouf University Saudi Arabia from September 2019 to August 2020 and comprised of 183 individuals (91 cases and 92 controls). The blood samples were drawn from the patients visiting two tertiary care settings of Al Jouf province. Biochemical analysis was conducted on various instruments, and serum TNF-α was measured by the ELISA method.

Results: The levels of serum glucose fasting, lipid profile, HbA1c and body mass index (BMI) were raised significantly in cases of MetS than controls (p = 0.001). Serum TNF-α was significantly higher in patients (58.04 ± 15.44) than controls (48.81 ± 10.30). It was correlated with the BMI, blood HbA1c, serum fasting glucose (SFG) and serum high density lipoprotein (HDL). The weak positive correlation was found with BMI (r = 0.18; p = 0.01), serum glucose (r = 0.21; p = 0.007) and HbA1c (r = 0.14; p = 0.04), but found negative association with serum HDL (r = -0.18; p = 0.01).

Conclusion: The serum TNF-α was raised in metabolic syndrome patients than the healthy controls. It was positively associated with high BMI, serum fasting glucose, and HbA1c and found linked and negatively linked to low HDL levels in MetS patients in the Saudi population.

doi: https://doi.org/10.12669/pjms.37.3.3897

How to cite this:
Ullah MI, Alzahrani B, Alsrhani A, Atif M, Alameen AAM, Ejaz H. Determination of serum tumor necrosis factor-alpha (TNF-α) levels in metabolic syndrome patients from Saudi population. Pak J Med Sci. 2021;37(3):700-705. doi: https://doi.org/10.12669/pjms.37.3.3897

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Muhammad Ikram Ullah, Jouf University

Assistant Professor

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences. 

Badr Alzahrani, Jouf University

Assistant Professor

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences. 

Abdullah Alsrhani, Jouf University

Assistant Professor

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences. 

Muhammad Atif, Jouf University

Assistant Professor

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences. 

Ayman Ali Mohammed Alameen, Jouf University

Assistant Professor

Department of Clinical Laboratory Sciences, College of Applied Medical Sciences. 

Hasan Ejaz, Jouf University

Associate Professor of Microbiology

Department of Clinical Laboratory Sciences

College of Applied Medical Sciences

Jouf University, Sakaka, Saudi Arabia

 

Published
2021-03-26
How to Cite
Ullah, M., Alzahrani, B., Alsrhani, A., Atif, M., Alameen, A., & Ejaz, H. (2021). Determination of serum tumor necrosis factor-alpha (TNF-α) levels in metabolic syndrome patients from Saudi population. Pakistan Journal of Medical Sciences, 37(3). https://doi.org/10.12669/pjms.37.3.3897
Section
Original Articles