Autoimmune cytopenias in chronic lymphocytic leukemia

Autoimmune cytopenias in chronic lymphocytic leukemia

  • Mohammad Shabih Haider Army Medical College, NUMS
  • Saleem Ahmed Khan Army Medical College, NUMS
  • Nasiruddin Khattak Army Medical College, NUMS
  • Samra Shahid Army Medical College, NUMS
Keywords: Chronic lymphocytic leukemia, Autoimmune hemolytic anaemia, Immune thrombocytopenic purpura, Red cell aplasia, Autoimmune granulocytopenia


Objective: To determine the frequency of autoimmune cytopenias in chronic lymphocytic leukemia.

Methods: This cross sectional study was carried out at Department of Hematology, Army Medical College Rawalpindi, in collaboration with Military Hospital Rawalpindi and Armed Forces institute of Pathology Rawalpindi from 1st January 2018 to 1st October 2018. Sample size of 64 was calculated using WHO calculator. Age and gender of patients was noted. Frequency of autoimmune hemolytic anaemia, immune thrombocytopenic purpura, pure red cell aplasia and autoimmune agranulocytosis were determined in diagnosed patients of chronic lymphocytic leukemia by various laboratory tests in our study population.

Results: A total of 64 patients were included in the study, 53 (82.8%) were males and 11(17.2%) were females. Mean age of patients was 65 years. Autoimmune hemolytic anaemia was observed in 5/64 (7.8%) of patients. Immune thrombocytopenic purpura was seen in 2/64 (3.1%) patients. Autoimmune granuloytopenia and pure red cell aplasia were not seen in any patient.

Conclusion: Autoimmune hemolytic anaemia and immune thrombocytopenic purpura are the most common causes of immune cytopenias in patients of CLL. Immune cytopenias should always be identified by laboratory tests as their management differs from other cytopenias which occur due to various other causes.


How to cite this:
Haider MS, Khan SA, Nasiruddin, Shahid S. Autoimmune cytopenias in chronic lymphocytic leukemia. Pak J Med Sci. 2019;35(5):1334-1338. doi:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to Cite
Haider, M., Khan, S., Khattak, N., & Shahid, S. (2019). Autoimmune cytopenias in chronic lymphocytic leukemia. Pakistan Journal of Medical Sciences, 35(5).
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