Focal Segmental Glomerulosclerosis in Paediatric Population of South Punjab Pakistan: A Tertiary Care Hospital Experience

  • Rabia Saleem Safdar Department of Pediatric Medicine, Nishtar Medical University Hospital, Multan
  • M Faisal Mehar DeDepartment of Pediatric Medicine, Nishtar Medical University Hospital, Multan
  • Afsheen Asghar Department of Pediatric Medicine, Nishtar Medical University Hospital, Multan
  • Nusrat Buzdar Department of Pediatric Medicine, Nishtar Medical University Hospital, Multan
Keywords: Focal segmental glomerulosclerosis,, complete remissioncomplete remission, end stage kidney disease, immunosuppressive drugs

Abstract

Objectives: To find out frequency, clinicopathological features, response of treatment and outcome among children with primary focal segmental glomerulosclerosis (FSGS).

Methods: This retrospective, non-interventional medical charts review study was conducted from a period of January 2011 to January 2020 at Pediatric Department of Nishtar Medical University Hospital, Multan, Pakistan. During the nine years study period, children of both genders, aged less than 16 years, with renal biopsies proven FSGS were included. Patient’s demographic along with clinical and laboratory data, urine dipstick for proteinuria, renal functions, 24 hours urinary protein and ultrasonography findings of kidneys, ureters and bladder (KUB) were noted from case records. Response rates of various treatment options and their outcome like remission, partial remission, no remission with stable kidney disease & no remission with progression of kidney disease were noted.

Results: During the study duration, out of 307 renal biopsies performed in glomerulonephritis cases, 124 (40.4%) had primary FSGS. In 124 primary FSGS cases, mean age was 8.83±3.05 years while most of the children, 70 (56.5%) were above 10 years of age. Majority of the cases, 64 (51.6%) were male. Mean follow up duration was noted to be 28.35+18.47 months. Most of the cases, 68 (54.8%) were found to have complete remission, 22 (17.7%) partial remission while 11 (8.9%) progressed to ESKD.

Conclusions: Among children, frequency of primary FSGS was high at our setting. Most of the cases achieved sustained remission rates with the help of immunosuppressive drugs. Cyclosporine and tacrolimus were found to be the most effective drugs.

doi: https://doi.org/10.12669/pjms.37.2.3535

How to cite this:
Safdar RS, Mehar MF, Khan AA, Buzdar N. Focal Segmental Glomerulosclerosis in Paediatric Population of South Punjab Pakistan: A Tertiary Care Hospital Experience. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.3535

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

M Faisal Mehar, DeDepartment of Pediatric Medicine, Nishtar Medical University Hospital, Multan

FCPS (Pediatric Medicine), Assistant Professor, Department of Pediatric Medicine, Nishtar Medical University Hospital, Multan

Afsheen Asghar, Department of Pediatric Medicine, Nishtar Medical University Hospital, Multan

FCPS (Pediatric Medicine), Assistant Professor, Department of Pediatric Medicine, Nishtar Medical University Hospital, Multan

 

Nusrat Buzdar, Department of Pediatric Medicine, Nishtar Medical University Hospital, Multan

FCPS (Pediatric Medicine), Assistant Professor, Department of Pediatric Medicine, Nishtar Medical University Hospital, Multan

Published
2021-01-02
How to Cite
Safdar, R., Mehar, M., Asghar, A., & Buzdar, N. (2021). Focal Segmental Glomerulosclerosis in Paediatric Population of South Punjab Pakistan: A Tertiary Care Hospital Experience. Pakistan Journal of Medical Sciences, 37(2). https://doi.org/10.12669/pjms.37.2.3535
Section
Original Articles