Increased ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome

  • Gokhan Cakirca Department of Biochemistry, Sanliurfa Mehmet Akif Inan Training and Research Hospital, Sanliurfa, Turkey.
  • Ahmet Guzelcicek Department of Pediatrics, Harran University, Faculty of Medicine, Sanliurfa, Turkey
  • Kenan Yilmaz Department of Pediatric Nephrology, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey
  • Cemal Nas Department of Biochemistry, Sanliurfa Training and Research Hospital, Sanliurfa, Turkey
Keywords: Ischemia modified albumin, Oxidative stress, Steroid-sensitive nephrotic syndrome

Abstract

Objective: Growing evidence shows that oxidative stress plays an important role in the development and progression of nephrotic syndrome (NS). In this study, we aimed to examine serum IMA levels as an indicator of oxidative stress in children with steroid-sensitive NS (SSNS) in remission and relapse.

Methods: This cross-sectional study was carried out at the Pediatric Nephrology Unit of Sanliurfa Training and Research Hospital, Sanliurfa, Turkey, from April 2019 to December 2019. In this study Serum IMA and albumin levels were determined in 70 children with SSNS and 45 healthy controls. Among the children with SSNS, 50 were in remission and 20 were in relapse. Then, adjusted IMA levels were calculated from the IMA/albumin ratio.

Results: IMA and adjusted IMA levels significantly increased and albumin significantly decreased in children with SSNS in relapse and remission compared with those of the healthy controls. Moreover, these alterations were more prominent in the relapse group than in the remission group. IMA was inversely correlated with albumin in children with SSNS (r= −0.881, p= <0.001).

Conclusions: Our findings demonstrated that elevated IMA and adjusted IMA levels observed in patients with SSNS were associated with increased oxidative stress and could indirectly reflect the degree of oxidative damage in glomerular structures.

doi: https://doi.org/10.12669/pjms.36.7.2924

How to cite this:
Cakirca G, Guzelcicek A, Yilmaz K, Nas C. Increased ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome. Pak J Med Sci. 2020;36(7):1490-1494. doi: https://doi.org/10.12669/pjms.36.7.2924

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2020-10-17
How to Cite
Cakirca, G., Guzelcicek, A., Yilmaz, K., & Nas, C. (2020). Increased ischemia-modified albumin levels in children with steroid-sensitive nephrotic syndrome. Pakistan Journal of Medical Sciences, 36(7). https://doi.org/10.12669/pjms.36.7.2924
Section
Original Articles