Clinical outcome of Montelukast Sodium in Children with Adenoid Hypertrophy

  • Syed Ali Naqi, Dr Islamabad Medical and Dental College
  • Ahmed Hassan Ashfaq, Dr Rawalpindi Medical University
  • Mumtaz Ahmad Umar, Dr Islamabad Medical and Dental College
  • Jais Kumar Karmani, Dr Islamabad Medical and Dental College
  • Naveed Arshad, Dr Islamabad Medical and Dental College https://orcid.org/0000-0003-1143-8959
Keywords: Adenoid, Hypertrophy, Montelukast sodium, Breathing, Obstructive sleep apnea syndrome

Abstract

Background & Objectives: Generally, the blockage of upper respiratory tract in children is seen with the hypertrophy of adenoids and tonsils. Normally for patients with adenoid hypertrophy (AH), Adenoidectomy with or without Tonsillectomy is carried out, however it has its own complications like haemorrhage and recurrence of adenoid tissue. Consequently, therapeutic approach has increased extraordinary consideration rather than surgical procedure. The inflammatory process proposed for AH has prompted the utilization of anti-inflammatory drugs to treat this issue. The objective of this study was to assess the impacts of Montelukast sodium in children with enlarged adenoids.

Methods: A randomized controlled trail was performed from April 2018 to March 2019 in the Otorhinolaryngology clinic of Dr. Akbar Niazi Teaching Hospital, Islamabad. In this randomized, placebo treatment-controlled trial, 60 children aged 4-12 years meeting inclusion criteria were isolated into two groups. The study group was treated with Montelukast sodium 5mg consistently for three months while the control group got placebo treatment for a similar timeframe. A questionnaire was filled by parents/ guardians of every child before and after the intervention to evaluate the severity of sleep discomfort, snoring and mouth breathing.

Results: Following 3 months of treatment, significant reduction in size of the adenoids was seen in 76% of study group compared with just 3% of control group getting placebo treatment.

Conclusion: Montelukast sodium seems to be effective in the reduction of the size of adenoids and improvement in clinical manifestations. It can be viewed as a viable option in contrast to surgical treatment in children with hypertrophy of adenoids.

doi: https://doi.org/10.12669/pjms.37.2.2670

How to cite this:
Naqi SA, Ashfaq AH, Umar MA, Karmani JK, Arshad N. Clinical outcome of Montelukast Sodium in Children with Adenoid Hypertrophy. Pak J Med Sci. 2021;37(2):---------. doi: https://doi.org/10.12669/pjms.37.2.2670

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Syed Ali Naqi, Dr, Islamabad Medical and Dental College

FCPS (ENT)

Associate Prefessor ENT

Ahmed Hassan Ashfaq, Dr, Rawalpindi Medical University

FCPS (ENT)

Associate Professor ENT

Mumtaz Ahmad Umar, Dr, Islamabad Medical and Dental College

FCPS (ENT)

Assistant Professor ENT

Jais Kumar Karmani, Dr, Islamabad Medical and Dental College

MD (Nephrology)

Assistant Professor Nephrology

Naveed Arshad, Dr, Islamabad Medical and Dental College

M.PHIL (Rehabilitation Sciences)

Assistant Professor Rehabilitation Sciences

Published
2021-01-04
How to Cite
Naqi, S., Ashfaq, A., Umar, M., Karmani, J., & Arshad, N. (2021). Clinical outcome of Montelukast Sodium in Children with Adenoid Hypertrophy. Pakistan Journal of Medical Sciences, 37(2). https://doi.org/10.12669/pjms.37.2.2670
Section
Original Articles