Primary Hyperparathyroidism: Experience from a Tertiary Care Centre in Pakistan

  • Tehseen Fatima aga Khan University
  • Bhagwan Das
  • Saadia Sattar
  • Najmul Islam
Keywords: Primary Hyperparathyroidism, Hypercalcemia, Osteitis fibrosa cystica

Abstract

Objective: To study the clinical, biochemical and radiological features and management outcomes of patients with primary hyperparathyroidism.

Methods: This retrospective study was conducted at the Aga Khan University Hospital, Karachi, Pakistan and comprised data of patients with primary hyperparathyroidism from 2008 to 2017.

Results: Out of 103 patients, 83(80.6%) were female. Overall mean age was 59.3±16.2 years. Musculoskeletal manifestations were seen in 60(58.3%) patients and renal manifestations in 28(27.2%). Ostieits fibrosa cystica was found in 04(3.88%) patients. Overall, Ultrasound neck and sestamibi scan localized the lesion in 66 (64.1%) and 77 (76.2%) patients respectively. Among 79 patients who underwent surgery, 67 (84.8%) patients had an adenoma, 05 (6.3%) had hyperplasia and 02(2.53%) patients had parathyroid carcinoma whereas histopathology was inconclusive in 5 (6.32%) out of the 79 surgically treated patients. Disease recurrence was seen in 13 out of 79(16.45%) patients who underwent surgery.

Conclusion: Primary hyperparathyroidism is associated with significant morbidity in our population. Targeted measures like improving patient awareness, routine calcium screening, vitamin D supplementation and a high index of suspicion by the clinician may help in early diagnosis of the condition and thus reduce morbidity.

doi: https://doi.org/10.12669/pjms.36.6.2572

How to cite this:
Fatima T, Das B, Sattar S, Islam N. Primary Hyperparathyroidism: Experience from a Tertiary Care Centre in Pakistan. Pak J Med Sci. 2020;36(6):---------. doi: https://doi.org/10.12669/pjms.36.6.2572

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2020-07-24
How to Cite
Fatima, T., Das, B., Sattar, S., & Islam, N. (2020). Primary Hyperparathyroidism: Experience from a Tertiary Care Centre in Pakistan. Pakistan Journal of Medical Sciences, 36(6). https://doi.org/10.12669/pjms.36.6.2572