Role of serum matrix metalloproteinase in the diagnosis of gastric cancer

  • Jian Liu Peiking University Third Hospital
  • Liya Zhou
  • Sanren Lin
  • Bei Yao
Keywords: Gastric cancer, Matrix metalloproteinase, Antibody array


Objective: To determine the clinical value of a matrix metalloproteinase (MMP) antibody array in diagnosing gastric cancer (GC).

Methods: In this prospective study, serum samples of patients with GC (n=66) and non-neoplastic gastric disease (NGD; n=34) were collected between November 2017 and July 2018. The quantitative measurement of 10 MMP-related proteins was done using MMP arrays and compared between the two groups.

Results: The serum levels of MMPs 3, 8, 9 and tissue inhibitor of metalloproteinases (TIMPs) 1 and 2 were significantly higher in the GC group than in the NGD group (p<0.05). The area under curve (AUC) of the 10 MMP proteins for the diagnosis of GC varied between 0.500 and 0.658. The total AUC of all MMPs was 0.897 (95% CI: 0.837-0.957). The total AUC of the five MMPs (MMPs 3, 8, 9, and TIMPs 1 and 2) was 0.821 (95% CI: 0.733-0.909) for diagnosing GC. Also, the 10-factor and 5-factor predictive models had good diagnostic ability for early GC with an AUC of 0.865 (95% CI: 0.753-0.977) and 0.749 (95% CI: 0.600-0.898), respectively.

Conclusions: The detection of multiple serum MMPs with protein biochip technology is promising to be used as a novel non-invasive tool for facilitating early diagnosis or screening of GC.


How to cite this:
Liu J, Zhou L, Lin S, Yao B. Role of serum matrix metalloproteinase in the diagnosis of gastric cancer. Pak J Med Sci. 2020;36(5):1025-1031. doi:

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

How to Cite
Liu, J., Zhou, L., Lin, S., & Yao, B. (2020). Role of serum matrix metalloproteinase in the diagnosis of gastric cancer. Pakistan Journal of Medical Sciences, 36(5).