Role of serum matrix metalloproteinase in the diagnosis of gastric cancer

  • Jian Liu Peiking University Third Hospital
  • Liya Zhou
  • Sanren Lin
  • Bei Yao
Keywords: Gastric cancer, Matrix metalloproteinase, Antibody array

Abstract

Objective: To determine the clinical value of a matrix metalloproteinase (MMP) antibody array in diagnosing gastric cancer (GC).

Methods: In this prospective study, serum samples of patients with GC (n=66) and non-neoplastic gastric disease (NGD; n=34) were collected between November 2017 and July 2018. The quantitative measurement of 10 MMP-related proteins was done using MMP arrays and compared between the two groups.

Results: The serum levels of MMPs 3, 8, 9 and tissue inhibitor of metalloproteinases (TIMPs) 1 and 2 were significantly higher in the GC group than in the NGD group (p<0.05). The area under curve (AUC) of the 10 MMP proteins for the diagnosis of GC varied between 0.500 and 0.658. The total AUC of all MMPs was 0.897 (95% CI: 0.837-0.957). The total AUC of the five MMPs (MMPs 3, 8, 9, and TIMPs 1 and 2) was 0.821 (95% CI: 0.733-0.909) for diagnosing GC. Also, the 10-factor and 5-factor predictive models had good diagnostic ability for early GC with an AUC of 0.865 (95% CI: 0.753-0.977) and 0.749 (95% CI: 0.600-0.898), respectively.

Conclusions: The detection of multiple serum MMPs with protein biochip technology is promising to be used as a novel non-invasive tool for facilitating early diagnosis or screening of GC.

doi: https://doi.org/10.12669/pjms.36.5.2059

How to cite this:
Liu J, Zhou L, Lin S, Yao B. Role of serum matrix metalloproteinase in the diagnosis of gastric cancer. Pak J Med Sci. 2020;36(5):1025-1031. doi: https://doi.org/10.12669/pjms.36.5.2059

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Published
2020-06-27
How to Cite
Liu, J., Zhou, L., Lin, S., & Yao, B. (2020). Role of serum matrix metalloproteinase in the diagnosis of gastric cancer. Pakistan Journal of Medical Sciences, 36(5). https://doi.org/10.12669/pjms.36.5.2059