Pentraxin-3 and inflammatory biomarkers related to posterolateral thoracotomy in Thoracic Surgery:

Isa Dongel; Ayşegül Aksoy Gökmen; Ibak Gönen; Selçuk Kaya

doi:10.12669/pjms.35.2.181

Isa Dongel Suleyman Demirel University, Faculty of Medicine, Department of Thoracic Surgery, Isparta https://orcid.org/0000-0003-2575-1882
Ayşegül Aksoy Gökmen 2. Kâtip Celebi University, Faculty of Medicine, Department of Medical Microbıology, İzmi https://orcid.org/0000-0001-6407-4592
Ibak Gönen Medical Park Silivri Hospital, Faculty of Medicine, Department of Infectious Disease, İstanbul https://orcid.org/0000-0002-2448-9897
Selçuk Kaya Kâtip Celebi University, Faculty of Medicine, Department of Medical Microbıology, İzmir https://orcid.org/0000-0002-8637-6345

DOI: https://doi.org/10.12669/pjms.35.2.181

Keywords: Pentraxin-3, C-reactive protein, Inflammatory biomarkers, Thoracotomy

Abstract

Objective: Posterolateral thoracotomy is the most frequently used operation in thoracic surgery, and may initiate an inflammatory process. We aimed to evaluate inflammatory response of the body to posterolateral thoracotomy.

Methods: This study was conducted between January 2013 and June 2014. Blood samples were drawn from 36 patients who underwent posterolateral thoracotomy preoperatively, and on postoperative days one, three and seven The levels of PTX-3,CRP and WBC in the serums of the patients were identified. All the results were recorded and analyzed.

Results: PTX-3 levels were found statistically significantly higher in patients with lung cancer and/or aged above 65 years. There were significant differences in WBC and CRP levels between preoperative levels and on those on postoperative days one, three and seven but not for PTX-3. The area under the curve(AUC) levels in the receiver operating characteristics(ROC) analysis, which was performed to estimate the strength of PTX-3 in the differentiation of malignant and benign patients was found statistically significant(p<0.05).

Conclusions: The present study suggests that the novel inflammatory marker PTX-3 may be used in the diagnosis and follow-up of prognosis as a biomarker of inflammatory response in patients with lung cancer. However, it showed that PTX-3 levels are insignificant to identify the levels of inflamatuar response due to posterolateral thoracotomy in thoracic surgery.

How to cite this:
Dongel I, Gokmen AA, Gonen I, Kaya S. Pentraxin-3 and inflammatory biomarkers related to posterolateral thoracotomy in Thoracic Surgery. Pak J Med Sci. 2019;35(2):464-469. doi: https://doi.org/10.12669/pjms.35.2.181

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Pentraxin-3 and inflammatory biomarkers related to posterolateral thoracotomy in Thoracic Surgery

Inflammatory Biomarkers Related to Posterolateral Thoracotomy

Abstract