Effect of pre-endoscopy intake of simethicone solution on endoscopic mucosal visibility: A single blinded, placebo control, randomized trial

Simethicone solution & endoscopic mucosal visibility

  • Bader Faiyaz Zuberi Dow University of Health Sciences
  • Majid Ahmed Shaikh Dow University of Health Sciences
  • Faiza Sadaqat Ali Dow University of Health Sciences
  • Tazeen Rasheed Dow University of Health Sciences
  • Zunaira Nawaz Dow University of Health Sciences
Keywords: Oesophago-gastro-duodenoscopy;, Randomized control trial, endoscopy, simethicone

Abstract

Objective: To determine effect of pre-endoscopy intake of simethicone solution on endoscopic mucosal visibility.

Methods: A randomized, single blinded placebo control trial was done in patients undergoing oesophago-gastro-duodenoscopy for any indication at DOTs Endoscopy Suite, CHK during the period of April to June 2019. Informed consent was taken. Patients were randomly allocated in two groups. Group-A received placebo while Group-B received Simethicone. Evaluation of mucosal visibility was assessed at 4 sites (oesophagus, fundus, antrum & duodenum) by previously validated scoring. Mean of visibility scores were compared in two groups.

Results: Two hundred and forty-eight patients were inducted and randomly allocate to two groups of 124 each. Mean of total sum of scores in Group-A was 8.14 ±2.44 and that of Group-B was 5.80 ±1.75 (p<0.001). Adequate visibility in Group-A was seen in 41.1% and that in Group-B was 78.2% (p<0.001).
Conclusion: Use of Simethicone significantly improves mucosal visibility during OGD.

doi: https://doi.org/10.12669/pjms.36.2.1241

How to cite this:
Zuberi BF, Shaikh MA, Ali FS, Rasheed T, Nawaz Z. Effect of pre-endoscopy intake of simethicone solution on endoscopic mucosal visibility: A single blinded, placebo control, randomized trial. Pak J Med Sci. 2020;36(2):172-176.  doi: https://doi.org/10.12669/pjms.36.2.1241

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Author Biographies

Majid Ahmed Shaikh, Dow University of Health Sciences

Assistant Professor

Faiza Sadaqat Ali, Dow University of Health Sciences

Senior Registrar

Tazeen Rasheed, Dow University of Health Sciences

Assistant Professor

Zunaira Nawaz, Dow University of Health Sciences

Assistant Professor

Published
2019-12-15
Section
Original Articles